Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20347981 | 0.87 | DDB1 (0.54) | GAAMEN1KMT2A | |
| SCHEMBL16008041 | 0.77 | GAA (0.54) | GAASIGMAR1MMP1MMP13 | |
| SCHEMBL20347991 | 0.77 | LMNA (0.44) | SIGMAR1OPRM1 | |
| SCHEMBL4719277 | 0.74 | DRD4 (0.46) | GAASIGMAR1MEN1KMT2AGSK3B | |
| SCHEMBL11432095 | 0.73 | GAA (0.68) | GAASIGMAR1MEN1KMT2AGSK3B | |
| SCHEMBL3553167 | 0.73 | SIGMAR1 (0.46) | GAASIGMAR1MEN1KMT2AOPRM1 | |
| SCHEMBL20133631 | 0.72 | SIGMAR1 (0.49) | GAASIGMAR1MEN1KMT2A | |
| SCHEMBL173296 | 0.72 | GAA (0.51) | GAASIGMAR1MEN1KMT2AGSK3B | |
| SCHEMBL28949764 | 0.72 | HPGD (0.74) | MEN1KMT2AGSK3B | |
| SCHEMBL2874555 | 0.72 | GAA (0.61) | GAASIGMAR1MEN1KMT2AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3875450-A1 | NRF2 ACTIVATOR | Biogen MA Inc. (US) | 2021-09-08 | — | — | EP | disclosed |
| EP-3562816-B1 | NRF2 ACTIVATOR | BIOGEN MA INC (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2018125880-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. (US) | 2018-07-05 | — | — | WO | disclosed |