Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | EDNRA | P25101 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20339142 | 0.90 | POLB (0.50) | KMT2AMEN1EDNRAALDH1A1LMNA | |
| SCHEMBL20354701 | 0.86 | SLC22A12 (0.47) | HTT | |
| SCHEMBL29560013 | 0.86 | SLC22A12 (0.47) | HTT | |
| SCHEMBL20355218 | 0.86 | EDNRA (0.45) | KMT2AMEN1EDNRAALDH1A1LMNA | |
| SCHEMBL30286552 | 0.86 | EDNRA (0.45) | KMT2AMEN1EDNRAALDH1A1LMNA | |
| SCHEMBL20354687 | 0.84 | ALDH1A1 (0.50) | KMT2AMEN1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL20355194 | 0.83 | MCL1 (0.42) | KMT2AMEN1EDNRAALDH1A1LMNA | |
| SCHEMBL29560848 | 0.83 | TMPRSS4 (0.43) | KMT2AMEN1EDNRAALDH1A1LMNA | |
| SCHEMBL30286695 | 0.83 | MCL1 (0.42) | KMT2AMEN1EDNRAALDH1A1LMNA | |
| SCHEMBL20354700 | 0.83 | TMPRSS4 (0.43) | KMT2AMEN1EDNRAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018122232-A1 | (AZA)INDOLE-, BENZOTHIOPHENE-, AND BENZOFURAN-3-SULFONAMIDES | UCB PHARMA GMBH (DE) | 2018-07-05 | — | — | WO | disclosed |