SCHEMBL2035532

SCHEMBL2035532

N#Cc1csc(-c2nnc(-c3ccc(F)nc3)o2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATR Q13535 2/20 0.46
CYP11B2 P19099 2/20 0.40
CYP2A6 P11509 3/20 0.39
CYP2B6 P20813 3/20 0.39
CYP2E1 P05181 1/20 0.39
CYP11B1 P15538 1/20 0.36
KDM1A O60341 1/20 0.35
RAB9A P51151 7/20 0.35
NPC1 O15118 6/20 0.35
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
BACE1 P56817 1/20 0.34
KDM4E B2RXH2 5/20 0.34
ALDH1A1 P00352 5/20 0.34
HPGD P15428 4/20 0.34
CYP3A4 P08684 2/20 0.34
CYP2C19 P33261 2/20 0.34
HSD17B10 Q99714 2/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2038123 0.78 RAB9A (0.59) CYP11B2CYP11B1RAB9ANPC1KDM4E
SCHEMBL2041592 0.78 ATR (0.40) ATRCYP11B2CYP11B1RAB9ANPC1
SCHEMBL3611591 0.77 NOTUM (0.50) ATRCYP11B2RAB9ANPC1ALDH1A1
SCHEMBL2042773 0.76 CYP11B2 (0.39) CYP11B2CYP2A6CYP2B6CYP2E1CYP11B1
SCHEMBL3612023 0.70 RAB9A (0.39) ATRCYP11B2CYP2A6CYP2B6CYP2E1
SCHEMBL3619213 0.69 NOTUM (0.49) ATRRAB9ANPC1MAOAMAOB
SCHEMBL3609349 0.68 NPC1 (0.66) CYP11B2RAB9ANPC1MAOAMAOB
SCHEMBL2539950 0.67 CYP11B2 (0.56) CYP11B2CYP2A6CYP2B6CYP2E1CYP11B1
SCHEMBL3612931 0.67 MMP3 (0.46) ATRCYP11B2CYP11B1RAB9ANPC1
SCHEMBL16420627 0.64 ATR (0.73) ATR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073299-A1 PYRIDINYL OXADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS NEUROSEARCH A/S (DK) 2011-06-23 WO claimed
WO-2011073299-A1 PYRIDINYL OXADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS NEUROSEARCH A/S (DK) 2011-06-23 WO disclosed