Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.49 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.49 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30286723 | 0.83 | MAOA (0.46) | MAPTKDM4EALDH1A1CDK4CCND1 | |
| SCHEMBL21569650 | 0.83 | MAOA (0.46) | MAPTKDM4EALDH1A1CDK4CCND1 | |
| SCHEMBL5520044 | 0.82 | MAPT (0.69) | MAPTKDM4EALDH1A1CDK4CCND1 | |
| SCHEMBL23620220 | 0.81 | TRPV4 (0.38) | MAPTKDM4EALDH1A1CDK4CCND1 | |
| SCHEMBL30991279 | 0.81 | SMN1; SMN2 (0.39) | MAPTKDM4EALDH1A1PRKAB2PRKAG1 | |
| SCHEMBL20354730 | 0.79 | MEN1 (0.47) | MAPTKDM4EHTR2AMEN1KMT2A | |
| SCHEMBL6109703 | 0.79 | MAPT (0.81) | MAPTKDM4EALDH1A1CDK4CCND1 | |
| SCHEMBL17850497 | 0.77 | GPR84 (0.51) | ALDH1A1LMNASMN1; SMN2TP53GPR84 | |
| SCHEMBL30684580 | 0.77 | GPR84 (0.51) | ALDH1A1LMNASMN1; SMN2TP53GPR84 | |
| SCHEMBL20266992 | 0.77 | NPC1 (0.56) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018122232-A1 | (AZA)INDOLE-, BENZOTHIOPHENE-, AND BENZOFURAN-3-SULFONAMIDES | UCB PHARMA GMBH (DE) | 2018-07-05 | — | — | WO | disclosed |