SCHEMBL20356136

SCHEMBL20356136

Brc1ccc2c(Br)ccc(Br)c2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.46
TLR9 Q9NR96 1/20 0.46
ALOX15 P16050 1/20 0.42
MAPK1 P28482 2/20 0.40
S100A4 P26447 1/20 0.40
ALDH1A1 P00352 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
CYP2A6 P11509 2/20 0.39
JAK2 O60674 3/20 0.38
METAP2 P50579 1/20 0.38
CHEK1 O14757 1/20 0.38
AURKA O14965 1/20 0.38
DAPK3 O43293 1/20 0.38
PRKD3 O94806 1/20 0.38
MAP4K4 O95819 1/20 0.38
PAK4 O96013 1/20 0.38
ABL1 P00519 1/20 0.38
NTRK1 P04629 1/20 0.38
CSF1R P07333 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28769250 0.83 HSP90AA1 (0.38) HSP90AA1TLR9ALOX15MAPK1S100A4
SCHEMBL28769627 0.83 HSP90AA1 (0.38) HSP90AA1TLR9ALOX15MAPK1S100A4
SCHEMBL598418 0.82 ALOX15 (0.42) HSP90AA1TLR9ALOX15MAPK1S100A4
SCHEMBL16158369 0.78 CYP2A6 (0.47) HSP90AA1TLR9ALOX15MAPK1S100A4
SCHEMBL20356135 0.76 ALOX15 (0.37) HSP90AA1TLR9ALOX15MAPK1ALDH1A1
SCHEMBL14973721 0.74 CYP2A6 (0.41) ALDH1A1CYP2A6
SCHEMBL28165045 0.74 MEN1 (0.46) HSP90AA1TLR9ALOX15MAPK1ALDH1A1
SCHEMBL31340097 0.74 MEN1 (0.46) HSP90AA1TLR9ALOX15MAPK1ALDH1A1
SCHEMBL6679360 0.73 GPR84 (0.41) HSP90AA1TLR9ALOX15MAPK1S100A4
SCHEMBL31049230 0.73 BCL2 (0.50) HSP90AA1TLR9ALOX15MAPK1S100A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3564245-A1 NAPHTHOBISCHALCOGENADIAZOLE DERIVATIVE AND PRODUCTION METHOD THEREFOR Osaka University (JP) 2019-11-06 EP disclosed
CN-108774143-A A kind of Triamine monomer and its preparation method and application centered on naphthalene structure 湖南工业大学 2018-11-09 CN disclosed
WO-2018123207-A1 NAPHTHOBISCHALCOGENADIAZOLE DERIVATIVE AND PRODUCTION METHOD THEREFOR 国立大学法人大阪大学 2018-07-05 WO disclosed
WO-2013183904-A1 COMPOUND CONTAINING BENZOFLUORENE FOR ORGANIC ELECTRONIC DEVICE, AND ORGANIC ELECTRONIC DEVICE AND ELECTRONIC APPARATUS USING SAME 덕산하이메탈(주) (KR) 2013-12-12 WO disclosed