Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.47 |
| ▸ | MEN1 | O00255 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20357366 | 0.80 | HDAC1 (0.40) | TSHRALDH1A1GAAHDAC1HDAC8 | |
| SCHEMBL862532 | 0.78 | TSHR (0.70) | TSHRKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL18615438 | 0.77 | KMT2A (0.42) | TSHRKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6005341 | 0.77 | GAA (0.69) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL20357330 | 0.76 | PDE4B (0.37) | — | |
| SCHEMBL18615449 | 0.76 | MEN1 (0.69) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL15123097 | 0.76 | ALDH1A1 (0.49) | MAPTALDH1A1MAPK1NPSR1LMNA | |
| SCHEMBL4317042 | 0.76 | KMT2A (0.73) | TSHRKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL14721362 | 0.76 | ALDH1A1 (0.52) | TSHRKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL20357363 | 0.75 | MAPT (0.58) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345893-B1 | UREA DERIVATIVE AND USE THEREFOR | TORAY INDUSTRIES (JP) | 2019-10-30 | — | — | EP | disclosed |
| US-10280145-B2 | Urea derivative and use therefor | TORAY INDUSTRIES, INC. (JP) | 2019-05-07 | — | — | US | disclosed |
| US-20180237398-A1 | UREA DERIVATIVE AND USE THEREFOR | TORAY INDUSTRIES, INC. (JP) | 2018-08-23 | — | — | US | disclosed |
| EP-3345893-A1 | UREA DERIVATIVE AND USE THEREFOR | Toray Industries, Inc. (JP) | 2018-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10280145-B2 | Urea derivative and use therefor | UTS2R, DDR1, WEE1 | TSHR 128/4885KMT2A 3875/4885MEN1 603/4885 |
| US-20180237398-A1 | UREA DERIVATIVE AND USE THEREFOR | UTS2R, DDR1, WEE1 | TSHR 128/4885KMT2A 3875/4885MEN1 603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.