Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2038641 | 0.84 | KMT2A (0.40) | KDM4EKDM4CALDH1A1DRD4AOC3 | |
| SCHEMBL3797644 | 0.75 | AOC3 (0.37) | KDM4CALDH1A1DRD4AOC3TSHR | |
| SCHEMBL2586558 | 0.75 | KDM4C (0.43) | KDM4EKDM4CALDH1A1DRD4AOC3 | |
| SCHEMBL2586566 | 0.75 | KDM4C (0.43) | KDM4EKDM4CALDH1A1DRD4AOC3 | |
| SCHEMBL2014387 | 0.74 | ALDH1A1 (0.34) | ALDH1A1DRD4AOC3TSHRGRM5 | |
| SCHEMBL2038164 | 0.74 | DRD4 (0.37) | KDM4EKDM4CALDH1A1DRD4AOC3 | |
| SCHEMBL2014210 | 0.73 | KDM4E (0.43) | KDM4EKDM4CDRD4TSHRMEN1 | |
| SCHEMBL2037647 | 0.73 | KDM4E (0.47) | KDM4EKDM4CDRD4TSHRMEN1 | |
| SCHEMBL26116319 | 0.73 | CYP1A2 (0.40) | KDM4EKDM4CALDH1A1HSD17B10 | |
| SCHEMBL2035758 | 0.72 | KDM4E (0.45) | KDM4EKDM4CALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |