Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 8/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2045853 | 0.86 | GAA (0.41) | GAATHRBKMT2AMEN1KDM4E | |
| SCHEMBL2040235 | 0.84 | LMNA (0.41) | GAATHRBKMT2AMEN1LMNA | |
| SCHEMBL15730305 | 0.81 | POLB (0.40) | GAAKMT2ALMNAKDM4EPOLB | |
| SCHEMBL13719690 | 0.81 | NTRK1 (0.51) | KMT2AMEN1LMNAKDM4EGABRA1 | |
| SCHEMBL2045688 | 0.80 | TP53 (0.40) | GAATHRBKMT2AMEN1LMNA | |
| SCHEMBL13719994 | 0.77 | KMT2A (0.36) | GAAKMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL11613205 | 0.75 | MEN1 (0.47) | GAATHRBKMT2AMEN1LMNA | |
| SCHEMBL16906269 | 0.75 | ALDH1A1 (0.39) | GAAKMT2AMEN1LMNAKDM4E | |
| SCHEMBL19155661 | 0.75 | ALKBH5 (0.42) | GAAKMT2AMEN1LMNAKDM4E | |
| SCHEMBL2042298 | 0.74 | NTRK1 (0.45) | GAATHRBKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140378668-A1 | Tyrosine Bioconjugation through Aqueous Ene-Like Reactions | SCRIPPS RESEARCH INST (US) | 2014-12-25 | — | — | US | disclosed |
| US-20140378668-A1 | Tyrosine Bioconjugation through Aqueous Ene-Like Reactions | SCRIPPS RESEARCH INST (US) | 2014-12-25 | — | — | US | disclosed |
| US-20140378668-A1 | Tyrosine Bioconjugation through Aqueous Ene-Like Reactions | SCRIPPS RESEARCH INST (US) | 2014-12-25 | — | — | US | disclosed |
| US-8765920-B2 | Tyrosine bioconjugation through aqueous Ene-like reactions | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-07-01 | — | — | US | disclosed |
| US-8765920-B2 | Tyrosine bioconjugation through aqueous Ene-like reactions | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-07-01 | — | — | US | disclosed |
| US-8765920-B2 | Tyrosine bioconjugation through aqueous Ene-like reactions | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120289682-A1 | Tyrosine Bioconjugation through Aqueous Ene-Like Reactions | THE SCRIPPS RESEARCH INSTITUTE | 2012-11-15 | — | — | US | disclosed |
| US-20120289682-A1 | Tyrosine Bioconjugation through Aqueous Ene-Like Reactions | THE SCRIPPS RESEARCH INSTITUTE | 2012-11-15 | — | — | US | disclosed |
| US-20120289682-A1 | Tyrosine Bioconjugation through Aqueous Ene-Like Reactions | THE SCRIPPS RESEARCH INSTITUTE | 2012-11-15 | — | — | US | disclosed |
| EP-2515914-A1 | TYROSINE BIOCONJUGATION THROUGH AQUEOUS ENE-LIKE REACTIONS | The Scripps Research Institute (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011079315-A1 | TYROSINE BIOCONJUGATION THROUGH AQUEOUS ENE-LIKE REACTIONS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378668-A1 | Tyrosine Bioconjugation through Aqueous Ene-Like Reactions | TYR, DNPEP, TH | GAA 410/4885THRB 1322/4885KMT2A 1218/4885 |
| US-20120289682-A1 | Tyrosine Bioconjugation through Aqueous Ene-Like Reactions | TYR, DNPEP, TH | GAA 410/4885THRB 1322/4885KMT2A 1218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.