Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20362229 | 0.92 | LIPG (0.33) | — | |
| SCHEMBL30324928 | 0.82 | HPGD (0.40) | — | |
| SCHEMBL23922040 | 0.82 | HPGD (0.40) | — | |
| SCHEMBL21070724 | 0.80 | CHRNB2 (0.31) | — | |
| SCHEMBL29874341 | 0.78 | PRMT5 (0.41) | — | |
| SCHEMBL16898784 | 0.77 | MGMT (0.36) | MGMT | |
| SCHEMBL16898524 | 0.77 | MGMT (0.36) | MGMT | |
| SCHEMBL16898595 | 0.77 | CRBN (0.32) | MGMT | |
| SCHEMBL16898643 | 0.77 | MGMT (0.36) | MGMT | |
| SCHEMBL16898349 | 0.77 | MGMT (0.36) | MGMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3565811-A1 | INHIBITORS OF NHE-MEDIATED ANTIPORT | Ardelyx, Inc. (US) | 2019-11-13 | — | — | EP | disclosed |
| WO-2018129557-A1 | INHIBITORS OF NHE-MEDIATED ANTIPORT | ARDELYX, INC. (US) | 2018-07-12 | — | — | WO | disclosed |