Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25504806 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2POLBNPSR1L3MBTL1HDAC1 | |
| SCHEMBL18375023 | 0.83 | CHRNB2 (0.38) | SMN1; SMN2POLBNPSR1L3MBTL1HDAC1 | |
| SCHEMBL16132851 | 0.80 | TLR9 (0.38) | SMN1; SMN2POLBNPSR1L3MBTL1CHRNB2 | |
| SCHEMBL1463933 | 0.79 | CHRNB2 (0.65) | SMN1; SMN2POLBNPSR1L3MBTL1CHRNB2 | |
| SCHEMBL24309126 | 0.78 | CHRNB2 (0.52) | SMN1; SMN2CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL19104799 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBNPSR1L3MBTL1HDAC1 | |
| SCHEMBL15490020 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL25075396 | 0.78 | CHRNB2 (0.52) | SMN1; SMN2CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL24974012 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2POLBNPSR1L3MBTL1CHRNB2 | |
| SCHEMBL16132848 | 0.78 | CHRNB2 (0.52) | SMN1; SMN2CHRNB2CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10421756-B2 | Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase | RODIN THERAPEUTICS, INC. (US) | 2019-09-24 | — | — | US | disclosed |
| US-20180194760-A1 | HETEROBICYCLIC N-AMINOPHENYL-AMIDES AS INHIBITORS OF HISTONE DEACETYLASE | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2018-07-12 | — | — | US | disclosed |
| US-20180194760-A1 | HETEROBICYCLIC N-AMINOPHENYL-AMIDES AS INHIBITORS OF HISTONE DEACETYLASE | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2018-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194760-A1 | HETEROBICYCLIC N-AMINOPHENYL-AMIDES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC2, HDAC1, HDAC5 | SMN1; SMN2 1390/4885POLB 874/4885NPSR1 1149/4885 |
| US-10421756-B2 | Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase | HDAC2, HDAC1, HDAC5 | SMN1; SMN2 1390/4885POLB 874/4885NPSR1 1149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.