Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22361502 | 0.94 | L3MBTL1 (0.58) | TDP1L3MBTL1MMP1MMP13ADAM17 | |
| SCHEMBL18400727 | 0.88 | L3MBTL1 (0.53) | TDP1L3MBTL1CYP2A6CYP1A2CYP3A4 | |
| SCHEMBL22430399 | 0.85 | TDP1 (0.58) | TDP1L3MBTL1CNR1CNR2MMP1 | |
| SCHEMBL13715387 | 0.84 | L3MBTL1 (0.55) | TDP1L3MBTL1CYP2A6CYP1A2CYP3A4 | |
| SCHEMBL11096844 | 0.81 | TDP1 (0.57) | TDP1L3MBTL1CNR1CNR2MMP1 | |
| SCHEMBL27498473 | 0.79 | TDP1 (0.58) | TDP1L3MBTL1CNR1CNR2MMP1 | |
| SCHEMBL25381172 | 0.77 | TDP1 (0.96) | TDP1L3MBTL1HRH1TRPV1CYP2A6 | |
| SCHEMBL25382598 | 0.77 | TDP1 (0.96) | TDP1L3MBTL1HRH1TRPV1CYP2A6 | |
| SCHEMBL6114977 | 0.77 | TDP1 (0.96) | TDP1L3MBTL1HRH1TRPV1CYP2A6 | |
| SCHEMBL25380936 | 0.77 | TDP1 (0.96) | TDP1L3MBTL1HRH1TRPV1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194757-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194757-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | TDP1 1229/4885L3MBTL1 2129/4885CNR1 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.