SCHEMBL20368770

SCHEMBL20368770

COc1c(O)cc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1Br

nearest known ligand 0.87

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
MYB P10242 18/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4331540 0.90 MYB (0.87) MYB
SCHEMBL4325696 0.87 MYB (0.78) MYB
SCHEMBL4335346 0.84 MYB (1.00) MYB
SCHEMBL4327922 0.83 MYB (0.83) MYB
SCHEMBL4541136 0.82 TUBB4A (0.69) MYB
SCHEMBL4534455 0.82 MYB (0.83) MYB
SCHEMBL5048163 0.82 MYB (0.89) MYB
SCHEMBL4539906 0.81 TUBB4A (0.65) MYB
SCHEMBL6014204 0.81 MYB (0.89) MYB
SCHEMBL5044963 0.81 MYB (0.89) MYB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2638025-B1 CHROMENE DERIVATIVES AND THEIR ANALOGA AS WNT PATHWAY ANTAGONISTS DEUTSCHES KREBSFORSCHUNGSZENTRUM DKFZ (DE) 2020-02-05 EP disclosed
EP-2638026-B1 CHROMENE DERIVATIVES AND THEIR ANALOGA AS WNT PATHWAY ANTAGONISTS DEUTSCHES KREBSFORSCHUNGSZENTRUM DKFZ (DE) 2018-07-11 EP disclosed