Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | NOX4 | Q9NPH5 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373579 | 0.89 | AR (0.37) | PLA2G2APDE1APDE1BPDE1CNOX4 | |
| SCHEMBL20373279 | 0.84 | PDE1A (0.40) | PLA2G2APDE1APDE1BPDE1CNOX4 | |
| SCHEMBL18326382 | 0.80 | HTR2A (0.43) | PLA2G2ANOX4KDM4EMEN1KMT2A | |
| SCHEMBL20373449 | 0.76 | SYK (0.38) | PLA2G2APDE1APDE1BPDE1CNOX4 | |
| SCHEMBL20373445 | 0.75 | TLR7 (0.33) | PLA2G2APDE1APDE1BPDE1CNOX4 | |
| SCHEMBL20373452 | 0.75 | KCNA5 (0.40) | PLA2G2APDE1APDE1BPDE1CNOX4 | |
| SCHEMBL20373585 | 0.75 | POLB (0.38) | PDE1APDE1BPDE1CKDM4EMEN1 | |
| SCHEMBL20373754 | 0.74 | TLR7 (0.37) | NOX4KDM4EPTGDR2SMN1; SMN2GRIN1 | |
| SCHEMBL20373284 | 0.74 | KDM4E (0.36) | PLA2G2APDE1APDE1BPDE1CNOX4 | |
| SCHEMBL18359530 | 0.74 | PDE1A (0.37) | PLA2G2APDE1APDE1BPDE1CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |