Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373449 | 0.88 | SYK (0.38) | TLR7SYKAURKBINCENPPLA2G2A | |
| SCHEMBL20373452 | 0.86 | KCNA5 (0.40) | TLR7SYKAURKBINCENPPLA2G2A | |
| SCHEMBL20373284 | 0.85 | KDM4E (0.36) | TLR7SYKAURKBINCENPPLA2G2A | |
| SCHEMBL20373754 | 0.84 | TLR7 (0.37) | TLR7NOX4GRIN1GRIN2BGABRA1 | |
| SCHEMBL20373360 | 0.83 | MET (0.40) | MEN1ALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL20373588 | 0.82 | BRD4 (0.37) | TLR7S1PR3PDE1BNOX4BRD4 | |
| SCHEMBL20373357 | 0.81 | NOX4 (0.43) | NOX4ALDH1A1BRD4KDM4E | |
| SCHEMBL20373361 | 0.81 | AVPR2 (0.34) | TLR7SYKALOX5APNOX4GABRA1 | |
| SCHEMBL20373288 | 0.79 | S1PR3 (0.37) | PLA2G2AS1PR3PDE1APDE1BPDE1C | |
| SCHEMBL20373279 | 0.78 | PDE1A (0.40) | SYKAURKBINCENPPLA2G2APDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |