Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373279 | 0.86 | PDE1A (0.40) | PDE1APDE1BPDE1CALDH1A1KDM4E | |
| SCHEMBL20373441 | 0.85 | PDE4A (0.39) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18326380 | 0.82 | PDE4D (0.42) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18359534 | 0.81 | ALDH1A1 (0.39) | POLBPDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL18359530 | 0.78 | PDE1A (0.37) | POLBPDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL16906007 | 0.76 | BRD4 (0.53) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL18359566 | 0.75 | GRM4 (0.39) | POLBPDE1APDE1BPDE1CMEN1 | |
| SCHEMBL20373356 | 0.75 | PLA2G2A (0.39) | POLBPDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL20373449 | 0.73 | SYK (0.38) | PDE1APDE1BPDE1C | |
| SCHEMBL20373588 | 0.73 | BRD4 (0.37) | PDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |