Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 3/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373449 | 0.86 | SYK (0.38) | TLR7GRIN1GRIN2BNOX4NTRK1 | |
| SCHEMBL20373758 | 0.84 | P2RX3 (0.35) | — | |
| SCHEMBL20373452 | 0.84 | KCNA5 (0.40) | TLR7NOX4GABRA5GABRA1 | |
| SCHEMBL20373445 | 0.84 | TLR7 (0.33) | TLR7KDM4EMAPTFEN1GRIN1 | |
| SCHEMBL20373284 | 0.84 | KDM4E (0.36) | TLR7KDM4ENOX4NTRK1SMN1; SMN2 | |
| SCHEMBL20373360 | 0.81 | MET (0.40) | KDM4EMAPTGAAHTT | |
| SCHEMBL20373588 | 0.80 | BRD4 (0.37) | TLR7NOX4BRD4 | |
| SCHEMBL20373357 | 0.80 | NOX4 (0.43) | KDM4ENOX4BRD4 | |
| SCHEMBL20373361 | 0.79 | AVPR2 (0.34) | TLR7KDM4ENOX4GABRA5GABRA1 | |
| SCHEMBL20373279 | 0.77 | PDE1A (0.40) | KDM4EMAPTFEN1NOX4GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |