Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16896809 | 0.73 | BRD4 (0.41) | CYP3A4CYP2C9 | |
| SCHEMBL20373746 | 0.69 | AKR1C3 (0.43) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL20373741 | 0.69 | LMNA (0.41) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL18326374 | 0.69 | HTR2A (0.41) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20373436 | 0.68 | FLT1 (0.39) | MAPTALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL18359595 | 0.66 | FFAR1 (0.42) | ALDH1A1CYP3A4CYP2C9P2RX3 | |
| SCHEMBL16896795 | 0.66 | HTR2A (0.41) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL16906139 | 0.64 | BRD4 (0.39) | CYP3A4CYP2C9 | |
| SCHEMBL20495558 | 0.64 | BRD4 (0.40) | CYP3A4CYP2C9P2RX3 | |
| SCHEMBL18359525 | 0.63 | BRD4 (0.44) | TP53CYP3A4CYP2C9P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |