Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18326374 | 0.86 | HTR2A (0.41) | LMNAALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL16905797 | 0.78 | BRD4 (0.42) | BRD4CYP3A4CYP2C9 | |
| SCHEMBL20373740 | 0.75 | MEN1 (0.41) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL16896795 | 0.74 | HTR2A (0.41) | LMNAALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL18359550 | 0.70 | BRD4 (0.40) | BRD4CYP3A4CYP2C9 | |
| SCHEMBL22549219 | 0.70 | GABRA5 (0.45) | ALDH1A1MAPTKMT2AMEN1BRD4 | |
| SCHEMBL16896809 | 0.69 | BRD4 (0.41) | BRD4CYP3A4CYP2C9 | |
| SCHEMBL16896824 | 0.69 | BRD4 (0.39) | BRD4RXFP1CYP3A4CYP2C9 | |
| SCHEMBL20373363 | 0.69 | MAPT (0.35) | LMNAALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL20357634 | 0.68 | BRD4 (0.40) | ALDH1A1SMN1; SMN2KMT2ARECQLBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |