Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373746 | 0.80 | AKR1C3 (0.43) | PPARGPTGS1PTGS2KDM4ELMNA | |
| SCHEMBL16896747 | 0.70 | BRD4 (0.44) | SCN9AKDM4EMAPK1 | |
| SCHEMBL20373363 | 0.68 | MAPT (0.35) | ALDH1A1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL20373756 | 0.67 | BRD4 (0.36) | ALDH1A1KDM4EHPGDBRD1BRPF1 | |
| SCHEMBL20373789 | 0.66 | PDE10A (0.41) | — | |
| SCHEMBL427119 | 0.63 | TUBB4A (0.53) | NOD2NOD1ALDH1A1LMNAMAPT | |
| SCHEMBL5250607 | 0.61 | PPARG (0.57) | FLT1FLT4KDRPPARGPPARA | |
| SCHEMBL31335990 | 0.61 | KDM4E (0.50) | FLT1FLT4KDRNOD2NOD1 | |
| SCHEMBL10143431 | 0.60 | NOD1 (0.53) | PPARGPPARANOD2NOD1PTGS1 | |
| SCHEMBL30920116 | 0.60 | NOD2 (0.47) | PPARGPPARANOD2NOD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |