Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SPTLC2 | O15270 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
| ▸ | TUBB | P07437 | 1/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373746 | 0.63 | AKR1C3 (0.43) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL24964824 | 0.61 | LMNA (0.54) | SMN1; SMN2MAPTMEN1KMT2APOLB | |
| SCHEMBL4418068 | 0.59 | LMNA (0.48) | SMN1; SMN2MEN1KMT2ANPC1LMNA | |
| SCHEMBL4418070 | 0.58 | LMNA (0.47) | SMN1; SMN2MEN1KMT2APOLBLMNA | |
| SCHEMBL6425432 | 0.57 | MEN1 (0.66) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL4429170 | 0.57 | LMNA (0.67) | SMN1; SMN2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL4429146 | 0.56 | LMNA (0.65) | SMN1; SMN2MEN1KMT2APOLBLMNA | |
| SCHEMBL4422567 | 0.56 | LMNA (0.79) | SMN1; SMN2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL8346666 | 0.56 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2APOLBLMNA | |
| SCHEMBL21187484 | 0.55 | JAK2 (0.42) | MAPTPOLBNPC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |