Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.63 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PGK1 | P00558 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370571 | 0.82 | SRC (0.57) | SRCKMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7984544 | 0.78 | SRC (1.00) | SRCGABRA1GABRA5ALDH1A1BRD4 | |
| SCHEMBL19896290 | 0.74 | SRC (0.62) | SRCGABRA1GABRA5MEN1KMT2A | |
| SCHEMBL16905989 | 0.73 | HTR2A (0.45) | SRCGABRA1GABRA5PDE4BMEN1 | |
| Hydrochloric Acid SCHEMBL19896459 | 0.72 | SRC (0.61) | SRCGABRA1GABRA5MEN1KMT2A | |
| SCHEMBL7970086 | 0.71 | SRC (0.63) | SRCKMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL28811123 | 0.71 | SRC (0.51) | SRCKMT2AALDH1A1KDM4EGFER | |
| SCHEMBL29868526 | 0.71 | SRC (0.51) | SRCKMT2AALDH1A1KDM4EGFER | |
| SCHEMBL13011169 | 0.71 | CNR2 (0.58) | SRCKMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL16818972 | 0.69 | GABRA1 (0.56) | GABRA1GABRA5ALDH1A1KDM4EGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |