Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373762 | 0.87 | KDM4E (0.37) | PLA2G2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL16896907 | 0.78 | PLA2G2A (0.41) | PLA2G2ABRD4KDM4EMEN1ALDH1A1 | |
| SCHEMBL16896825 | 0.76 | HTR2A (0.44) | PLA2G2ABRD4KDM4EMEN1ALDH1A1 | |
| SCHEMBL20373280 | 0.76 | POLB (0.37) | PLA2G2AKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL20373780 | 0.74 | ALDH1A1 (0.37) | PLA2G2AKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL16906006 | 0.74 | BRD4 (0.41) | PLA2G2ABRD4NOX4GRIN1GRIN2B | |
| SCHEMBL18326403 | 0.73 | KDM4E (0.40) | PLA2G2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL16896944 | 0.72 | GRIN1 (0.39) | PLA2G2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL16896777 | 0.72 | GRIN1 (0.44) | BRD4GRIN1GRIN2B | |
| SCHEMBL20547367 | 0.71 | KMT2A (0.54) | PLA2G2ABRD4KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |