Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373780 | 0.83 | ALDH1A1 (0.37) | POLBKDM4EALDH1A1PLA2G2ARAB9A | |
| SCHEMBL20373762 | 0.80 | KDM4E (0.37) | KDM4EALDH1A1PLA2G2ARAB9AHPGD | |
| SCHEMBL16896825 | 0.78 | HTR2A (0.44) | KDM4EALDH1A1PLA2G2AGRIN1GRIN2B | |
| SCHEMBL16896907 | 0.78 | PLA2G2A (0.41) | KDM4EALDH1A1PLA2G2AGRIN1GRIN2B | |
| SCHEMBL20373288 | 0.78 | S1PR3 (0.37) | KDM4EALDH1A1PLA2G2AHPGDGRIN1 | |
| SCHEMBL20373445 | 0.78 | TLR7 (0.33) | KDM4EALDH1A1PLA2G2AGRIN1GRIN2B | |
| SCHEMBL20373449 | 0.77 | SYK (0.38) | PLA2G2AGRIN1GRIN2BPDE1APDE1B | |
| SCHEMBL20373279 | 0.76 | PDE1A (0.40) | KDM4EALDH1A1PLA2G2ARAB9ANPC1 | |
| SCHEMBL20373764 | 0.76 | PLA2G2A (0.38) | KDM4EALDH1A1PLA2G2AGRIN1GRIN2B | |
| SCHEMBL20373452 | 0.76 | KCNA5 (0.40) | PLA2G2APDE1APDE1BPDE1CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |