Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | HSD17B13 | Q7Z5P4 | 2/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373274 | 0.79 | PDE5A (0.38) | PDE5A | |
| SCHEMBL20373789 | 0.78 | PDE10A (0.41) | — | |
| SCHEMBL20373449 | 0.74 | SYK (0.38) | PDE5AGRIN1GRIN2B | |
| SCHEMBL20373279 | 0.73 | PDE1A (0.40) | — | |
| SCHEMBL20373452 | 0.73 | KCNA5 (0.40) | PDE5A | |
| SCHEMBL20373445 | 0.73 | TLR7 (0.33) | GRIN1GRIN2B | |
| SCHEMBL18326387 | 0.73 | BRD4 (0.46) | SCN9A | |
| SCHEMBL20373756 | 0.73 | BRD4 (0.36) | — | |
| SCHEMBL20373284 | 0.73 | KDM4E (0.36) | — | |
| SCHEMBL20373754 | 0.72 | TLR7 (0.37) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |