Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPRA | P18433 | 1/20 | 0.32 |
| ▸ | PTPRB | P23467 | 1/20 | 0.32 |
| ▸ | PTPRE | P23469 | 1/20 | 0.32 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20375230 | 0.81 | IDO1 (0.41) | IDO1RAPGEF4MAP2K1PTK2PTPRC | |
| SCHEMBL23964485 | 0.79 | IDO1 (0.40) | IDO1RAPGEF4MAP2K1PTK2PTPRC | |
| SCHEMBL6561965 | 0.79 | IDO1 (0.40) | IDO1RAPGEF4MAP2K1PTK2PTPRC | |
| SCHEMBL9229807 | 0.78 | RAPGEF4 (0.56) | RAPGEF4GAAMEN1KMT2ATDP1 | |
| SCHEMBL13783444 | 0.76 | CYP3A4 (0.46) | IDO1MAP2K1PTPRCPTPN2PTPN1 | |
| SCHEMBL18618506 | 0.76 | IDO1 (0.38) | IDO1RAPGEF4MAP2K1PTK2PTPRC | |
| SCHEMBL18618504 | 0.76 | IDO1 (0.38) | IDO1RAPGEF4MAP2K1PTK2PTPRC | |
| SCHEMBL21844929 | 0.74 | ALDH1A1 (0.42) | MEN1KMT2ATDP1MAPT | |
| SCHEMBL3219456 | 0.74 | IDO1 (0.50) | IDO1PTPRCPTPN2PTPN1PTPRA | |
| SCHEMBL1748052 | 0.74 | IDO1 (0.40) | IDO1MAP2K1PTPRCPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345907-B1 | PYRAZOLO[3,4-D]PYRIMIDINE COMPOUNDS OR SALTS THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2020-04-22 | — | — | EP | disclosed |
| EP-3345907-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUND OR SALT THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2018-07-11 | — | — | EP | disclosed |