Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 13/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306241 | 0.91 | APP (0.47) | APPMAPTTPMT | |
| SCHEMBL20015758 | 0.91 | APP (0.47) | APPMAPTTPMT | |
| SCHEMBL2865734 | 0.83 | APP (0.74) | APPMAPT | |
| SCHEMBL18649211 | 0.82 | APP (0.41) | APPMAPTTPMT | |
| SCHEMBL16501329 | 0.80 | APP (0.67) | APPMAPT | |
| SCHEMBL16675523 | 0.78 | CYP1A1 (0.50) | APPMAPT | |
| SCHEMBL16675512 | 0.78 | CYP1A1 (0.50) | APPMAPT | |
| SCHEMBL21564900 | 0.78 | GRM5 (0.52) | APPMAPT | |
| SCHEMBL12824286 | 0.78 | ACACB (0.44) | APP | |
| SCHEMBL5484564 | 0.77 | APP (0.41) | APPTPMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470198-B2 | Mesogenic compounds comprising discotic and calamitic groups | MERCK PATENT GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| US-8470198-B2 | Mesogenic compounds comprising discotic and calamitic groups | MERCK PATENT GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| US-8470198-B2 | Mesogenic compounds comprising discotic and calamitic groups | MERCK PATENT GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| EP-2313474-B1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | MERCK PATENT GMBH (DE) | 2012-09-05 | — | — | EP | disclosed |
| EP-2313474-B1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | MERCK PATENT GMBH (DE) | 2012-09-05 | — | — | EP | disclosed |
| US-20110147659-A1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-06-23 | — | — | US | disclosed |
| US-20110147659-A1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-06-23 | — | — | US | disclosed |
| WO-2010020312-A1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | MERCK PATENT GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110147659-A1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | CALD1, DIAPH1, CALR | APP 3249/4885MAPT 647/4885TPMT 4191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.