Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29224308 | 0.84 | ALDH1A1 (0.42) | KDM4ESMN1; SMN2HSD17B10GAATSHR | |
| SCHEMBL19768898 | 0.83 | KDM4E (0.40) | KDM4ESMN1; SMN2HSD17B10GAATSHR | |
| SCHEMBL3580133 | 0.79 | LMNA (0.54) | KDM4ESMN1; SMN2HSD17B10GAATSHR | |
| SCHEMBL6052434 | 0.76 | KDM4E (0.41) | KDM4ESMN1; SMN2HSD17B10GAATSHR | |
| SCHEMBL6156758 | 0.75 | KDM4E (0.41) | KDM4ESMN1; SMN2HSD17B10GAATSHR | |
| SCHEMBL1304161 | 0.73 | SMN1; SMN2 (0.41) | KDM4ESMN1; SMN2HSD17B10GAATSHR | |
| SCHEMBL17438003 | 0.73 | KDM4E (0.40) | KDM4ESMN1; SMN2HSD17B10GAATSHR | |
| SCHEMBL4716984 | 0.73 | AGTR1 (0.42) | KDM4ESMN1; SMN2ALDH1A1TDP1SPR | |
| SCHEMBL6052538 | 0.72 | KMT2A (0.55) | KDM4ESMN1; SMN2HSD17B10GAATSHR | |
| SCHEMBL28976515 | 0.71 | KDM4E (0.38) | KDM4ESMN1; SMN2HSD17B10GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10344026-B2 | Compositions and methods of targeting mutant K-ras | NANTBIO, INC. (US) | 2019-07-09 | — | — | US | disclosed |
| US-20180201610-A1 | COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS | NANTBIO, INC. | 2018-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10344026-B2 | Compositions and methods of targeting mutant K-ras | KRAS, NRAS, HRAS | KDM4E 3378/4885SMN1; SMN2 3468/4885HSD17B10 3966/4885 |
| US-20180201610-A1 | COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS | KRAS, NRAS, HRAS | KDM4E 3378/4885SMN1; SMN2 3468/4885HSD17B10 3966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.