SCHEMBL20379568

SCHEMBL20379568

O=C1[C]=C(O)C(c2ccc(Br)cc2)N1c1ccc2[nH]cnc2c1

nearest known ligand 0.42

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ QPCT Q16769 17/20 0.42
▸ QPCTL Q9NXS2 1/20 0.38
▸ RXFP1 Q9HBX9 2/20 0.38
▸ ATM Q13315 1/20 0.38
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ CCR1 P32246 1/20 0.35
▸ CCR2 P41597 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20379509 0.89 QPCT (0.54) QPCTQPCTL
SCHEMBL21373597 0.89 QPCT (0.54) QPCTQPCTLCCR1CCR2
SCHEMBL20379989 0.89 QPCT (0.45) QPCTQPCTLCCR1
SCHEMBL21373544 0.89 QPCT (0.53) QPCTQPCTL
SCHEMBL20379086 0.88 QPCT (0.42) QPCTQPCTL
SCHEMBL21373626 0.86 QPCT (0.44) QPCTQPCTL
SCHEMBL21373648 0.76 QPCT (0.36) QPCT
SCHEMBL20379081 0.76 NOS1 (0.44) RXFP1ATMMEN1KMT2ACCR1
SCHEMBL21373484 0.76 QPCT (0.36) QPCTQPCTL
SCHEMBL21373610 0.72 QPCT (0.34) QPCTQPCTL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3568133-B1 CELL-PROTECTIVE COMPOUNDS AND THEIR USE ETH ZUERICH (CH) 2023-12-13 — — EP claimed
US-11628159-B2 Cell-protective compounds and their use ETH ZURICH (CH) 2023-04-18 — — US claimed
EP-3768673-A1 COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES ETH Zurich (CH) 2021-01-27 — — EP claimed
US-20210015793-A1 COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES ETH ZURICH (CH) 2021-01-21 — — US claimed
EP-3568133-A1 CELL-PROTECTIVE COMPOUNDS AND THEIR USE ETH Zurich (CH) 2019-11-20 — — EP claimed
US-20190343802-A1 CELL-PROTECTIVE COMPOUNDS AND THEIR USE ETH Zürich (CH) 2019-11-14 — — US claimed
WO-2019179890-A1 COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES ETH ZURICH (CH) 2019-09-26 — — WO claimed
EP-3543231-A1 COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES ETH Zurich (CH) 2019-09-25 — — EP claimed
WO-2018130537-A1 CELL-PROTECTIVE COMPOUNDS AND THEIR USE ETH Zürich (CH) 2018-07-19 — — WO claimed
EP-3568133-B1 CELL-PROTECTIVE COMPOUNDS AND THEIR USE ETH ZUERICH (CH) 2023-12-13 — — EP disclosed
CN-116462666-A Cytoprotective compounds and uses thereof 瑞士苏黎世联邦理工学院 2023-07-21 — — CN disclosed
US-11628159-B2 Cell-protective compounds and their use ETH ZURICH (CH) 2023-04-18 — — US disclosed
EP-3768673-A1 COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES ETH Zurich (CH) 2021-01-27 — — EP disclosed
US-20210015793-A1 COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES ETH ZURICH (CH) 2021-01-21 — — US disclosed
EP-3568133-A1 CELL-PROTECTIVE COMPOUNDS AND THEIR USE ETH Zurich (CH) 2019-11-20 — — EP disclosed
US-20190343802-A1 CELL-PROTECTIVE COMPOUNDS AND THEIR USE ETH Zürich (CH) 2019-11-14 — — US disclosed
WO-2019179890-A1 COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES ETH ZURICH (CH) 2019-09-26 — — WO disclosed
EP-3543231-A1 COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES ETH Zurich (CH) 2019-09-25 — — EP disclosed
WO-2018130537-A1 CELL-PROTECTIVE COMPOUNDS AND THEIR USE ETH Zürich (CH) 2018-07-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190343802-A1 CELL-PROTECTIVE COMPOUNDS AND THEIR USE SRPK2, SRSF2, SRPK1 QPCT 4373/4885QPCTL 4255/4885RXFP1 1002/4885
US-20210015793-A1 COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES PPT1, SPTLC1, LPCAT1 QPCT 776/4885QPCTL 1175/4885RXFP1 3030/4885
US-11628159-B2 Cell-protective compounds and their use SRPK2, SRSF2, SRPK1 QPCT 4373/4885QPCTL 4255/4885RXFP1 1002/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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