Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 17/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29258623 | 0.85 | NAMPT (0.57) | NAMPTALDH1A1RAB9AHTT | |
| SCHEMBL20389230 | 0.79 | NAMPT (1.00) | NAMPT | |
| SCHEMBL5722111 | 0.79 | KMT2A (0.56) | ALDH1A1RAB9A | |
| SCHEMBL20380235 | 0.78 | NAMPT (0.61) | NAMPTALDH1A1RAB9A | |
| SCHEMBL2056377 | 0.77 | RAB9A (0.74) | NAMPTRAB9AHTT | |
| SCHEMBL20379622 | 0.76 | NAMPT (0.55) | NAMPTALDH1A1RAB9AHTT | |
| SCHEMBL11747002 | 0.73 | NAMPT (0.73) | NAMPTHTT | |
| SCHEMBL8212768 | 0.73 | NAMPT (0.84) | NAMPTRAB9AHTT | |
| SCHEMBL11748446 | 0.73 | NAMPT (0.73) | NAMPTHTT | |
| SCHEMBL11718282 | 0.73 | IMPDH2 (0.65) | NAMPTALDH1A1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3568390-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-11-20 | — | — | EP | disclosed |
| WO-2018132372-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2018-07-19 | — | — | WO | disclosed |