Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 13/20 | 0.44 |
| ▸ | CA12 | O43570 | 12/20 | 0.44 |
| ▸ | CA1 | P00915 | 12/20 | 0.44 |
| ▸ | CA9 | Q16790 | 12/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162690 | 0.81 | CA1 (0.41) | CA2CA12CA1CA9CA7 | |
| SCHEMBL16861415 | 0.80 | CA12 (0.56) | CA2CA12CA1CA9CA7 | |
| SCHEMBL7737219 | 0.79 | CA1 (0.46) | CA2CA12CA1CA9 | |
| SCHEMBL20379673 | 0.79 | NAMPT (0.65) | ALDH1A1RAB9A | |
| SCHEMBL11427182 | 0.78 | CNR1 (0.42) | KMT2ACA2CA12CA1CA9 | |
| SCHEMBL14289782 | 0.78 | KMT2A (0.58) | KMT2ACA2CA12CA1CA9 | |
| SCHEMBL27441962 | 0.76 | ALDH1A1 (0.49) | KMT2AALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL12060955 | 0.75 | HTT (0.56) | KMT2ACA2CA12CA1CA9 | |
| SCHEMBL13180239 | 0.75 | ALDH1A1 (0.56) | KMT2ACA2CA9ALDH1A1CA4 | |
| SCHEMBL16705175 | 0.73 | ENPP2 (0.54) | KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673369-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | AstraZeneca AB (SE) | 2006-06-28 | — | — | EP | claimed |
| WO-2005030761-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | claimed |