Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.52 |
| ▸ | BCHE | P06276 | 4/20 | 0.52 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KAT7 | O95251 | 1/20 | 0.43 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12628523 | 1.00 | HTR6 (0.52) | HTR6BCHEACKR3KDM4EPKM | |
| SCHEMBL2011798 | 0.96 | KDM4E (0.51) | HTR6BCHEACKR3KDM4EPKM | |
| SCHEMBL2011799 | 0.96 | KDM4E (0.51) | HTR6BCHEACKR3KDM4EPKM | |
| SCHEMBL12628193 | 0.96 | KDM4E (0.51) | HTR6BCHEACKR3KDM4EPKM | |
| SCHEMBL2014458 | 0.91 | KDM4E (0.56) | HTR6KDM4EPKMTGFBR1STS | |
| SCHEMBL12628178 | 0.91 | KDM4E (0.56) | HTR6KDM4EPKMTGFBR1STS | |
| SCHEMBL12628959 | 0.83 | STS (0.41) | HTR6BCHEKDM4EPKMMMP13 | |
| SCHEMBL2012363 | 0.82 | USP30 (0.52) | MMP13MMP1MMP9TGFBR1TACR1 | |
| SCHEMBL12628525 | 0.82 | USP30 (0.52) | MMP13MMP1MMP9TGFBR1TACR1 | |
| SCHEMBL12628291 | 0.81 | ALDH1A1 (0.44) | MMP13MMP1MMP9TGFBR1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073269-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | claimed |