⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24816728 | 0.95 | — | — | |
| SCHEMBL12292038 | 0.76 | — | — | |
| SCHEMBL23155079 | 0.76 | — | — | |
| SCHEMBL3431415 | 0.75 | POLB (0.31) | — | |
| SCHEMBL19057205 | 0.73 | LMNA (0.32) | — | |
| SCHEMBL16541993 | 0.71 | — | — | |
| SCHEMBL20434567 | 0.71 | ALDH1A1 (0.35) | — | |
| SCHEMBL21899209 | 0.70 | — | — | |
| SCHEMBL25156605 | 0.67 | — | — | |
| SCHEMBL19266236 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11110177-B2 | ASH1L degraders and methods of treatment therewith | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-09-07 | — | — | US | disclosed |
| WO-2021062176-A2 | POLYMERIC TANDEM DYES WITH LINKER GROUPS | SONY CORPORATION (JP) | 2021-04-01 | — | — | WO | disclosed |
| US-20190142961-A1 | ASH1L DEGRADERS AND METHODS OF TREATMENT THEREWITH | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-05-16 | — | — | US | disclosed |
| US-10022453-B2 | Antibody drug conjugates (ADCs) with kinesin spindel protein (KSP) | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-07-17 | — | — | US | disclosed |