Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
| ▸ | WNT3A | P56704 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | HSD17B3 | P37058 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9419411 | 0.87 | KMT2A (0.69) | KMT2ACTNNB1WNT3AGSK3BHSD17B3 | |
| SCHEMBL8402203 | 0.85 | KMT2A (0.67) | KMT2ACTNNB1WNT3AGSK3BHSD17B3 | |
| SCHEMBL2325662 | 0.83 | KMT2A (0.60) | KMT2ACTNNB1WNT3AGSK3BHSD17B3 | |
| SCHEMBL29087029 | 0.81 | KMT2A (0.58) | KMT2ACTNNB1WNT3AGSK3BHSD17B3 | |
| SCHEMBL10881407 | 0.81 | KMT2A (0.58) | KMT2ACTNNB1WNT3AGSK3BHSD17B3 | |
| SCHEMBL13493042 | 0.80 | HDAC8 (0.64) | KMT2AGSK3BNPC1RAB9AL3MBTL1 | |
| SCHEMBL9125496 | 0.80 | KMT2A (0.56) | KMT2ACTNNB1WNT3AGSK3BHSD17B3 | |
| SCHEMBL10792888 | 0.79 | KMT2A (0.60) | KMT2ACTNNB1WNT3AGSK3BHSD17B3 | |
| SCHEMBL8525199 | 0.79 | HSD17B3 (0.72) | KMT2AGSK3BHSD17B3L3MBTL1TDP1 | |
| SCHEMBL5849125 | 0.79 | KMT2A (0.78) | KMT2AGSK3BHSD17B3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594563-B1 | 2-acylaminopropanol-type glucosylceramide synthase inhibitors | GENZYME CORP (US) | 2018-07-18 | — | — | EP | disclosed |