Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20385083 | 0.82 | CYP1A2 (0.47) | RAB9ANPC1KMT2AMEN1LMNA | |
| SCHEMBL20385134 | 0.82 | POLB (0.43) | HTTRAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL20385092 | 0.79 | HTT (0.41) | HTTRAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL20385091 | 0.75 | SIGMAR1 (0.38) | HTTRAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL15541786 | 0.74 | HTT (0.64) | HTTRAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL20385090 | 0.70 | SIGMAR1 (0.42) | HTTL3MBTL1SIGMAR1 | |
| SCHEMBL20385093 | 0.66 | HDAC1 (0.41) | RAB9ANPC1KMT2AMEN1SIGMAR1 | |
| SCHEMBL15463572 | 0.65 | HTT (0.70) | HTTRAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL20385169 | 0.65 | SIGMAR1 (0.44) | RAB9ANPC1KMT2AMEN1L3MBTL1 | |
| SCHEMBL20385168 | 0.64 | SIGMAR1 (0.40) | RAB9ANPC1KMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867215-B1 | TETRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | SANIONA AS (DK) | 2018-07-18 | — | — | EP | disclosed |