Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2046508 | 0.84 | KDM4E (0.37) | KMT2AMEN1HTTKDM4EDRD4 | |
| SCHEMBL2586558 | 0.76 | KDM4C (0.43) | KMT2AMEN1KDM4EDRD4AOC3 | |
| SCHEMBL2586566 | 0.76 | KDM4C (0.43) | KMT2AMEN1KDM4EDRD4AOC3 | |
| SCHEMBL2038164 | 0.75 | DRD4 (0.37) | KMT2AMEN1HTTKDM4EDRD4 | |
| SCHEMBL2014210 | 0.74 | KDM4E (0.43) | KMT2AMEN1HTTKDM4EDRD4 | |
| SCHEMBL2037647 | 0.74 | KDM4E (0.47) | KMT2AMEN1HTTKDM4EDRD4 | |
| SCHEMBL3797644 | 0.72 | AOC3 (0.37) | KMT2AMEN1HTTDRD4AOC3 | |
| SCHEMBL2014387 | 0.72 | ALDH1A1 (0.34) | KMT2AMEN1HTTDRD4AOC3 | |
| SCHEMBL25519339 | 0.72 | HTT (0.36) | KMT2AMEN1HTTDRD4ALDH1A1 | |
| SCHEMBL498175 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |