Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | FPR1 | P21462 | 2/20 | 0.48 |
| ▸ | MLKL | Q8NB16 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16516059 | 0.82 | AAK1 (0.48) | ALDH1A1CYP1A2L3MBTL1LMNA | |
| SCHEMBL2937870 | 0.81 | TSHR (0.63) | KMT2AIDO1ALOX12CYP2C9CYP3A4 | |
| SCHEMBL17910431 | 0.81 | RAB9A (0.53) | KMT2ACYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7478091 | 0.81 | HSD17B10 (0.46) | KMT2A | |
| SCHEMBL5126955 | 0.80 | KMT2A (0.39) | KMT2ACYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL5129452 | 0.80 | KMT2A (0.39) | KMT2ACYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL6532735 | 0.77 | KMT2A (0.50) | KMT2AIDO1ALOX12CYP2C9CYP3A4 | |
| SCHEMBL2040504 | 0.77 | PDE2A (0.48) | KMT2A | |
| SCHEMBL1928585 | 0.76 | KDM4E (0.55) | KMT2ACYP2C19ALDH1A1CYP1A2POLB | |
| SCHEMBL29701262 | 0.75 | IDO1 (0.54) | KMT2AIDO1ALOX12CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |