Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PRCP | P42785 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | F9 | P00740 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15158071 | 0.84 | PRCP (0.48) | KMT2APRCPHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL5126955 | 0.81 | KMT2A (0.39) | KMT2APRCPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7478091 | 0.80 | HSD17B10 (0.46) | KMT2AHSD17B10F9 | |
| SCHEMBL2038892 | 0.80 | KMT2A (0.58) | KMT2ACYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL2040504 | 0.78 | PDE2A (0.48) | KMT2APDE2A | |
| SCHEMBL7921079 | 0.76 | AAK1 (0.47) | PRCP | |
| SCHEMBL16516059 | 0.76 | AAK1 (0.48) | CYP1A2ALDH1A1SCN10A | |
| SCHEMBL1390562 | 0.75 | ALDH1A1 (0.37) | KMT2APRCPHSD17B10S1PR4S1PR1 | |
| SCHEMBL5029652 | 0.75 | HSD17B10 (0.53) | KMT2AHSD17B10CYP1A2S1PR4S1PR1 | |
| SCHEMBL7132733 | 0.74 | MMP1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993536-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007103755-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |