Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 19/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2041450 | 0.87 | CTSA (0.46) | CTSA | |
| SCHEMBL1847872 | 0.85 | CTSA (0.38) | CTSA | |
| SCHEMBL7825710 | 0.82 | CTSA (0.47) | CTSA | |
| SCHEMBL1975745 | 0.82 | FBP1 (0.39) | CTSA | |
| SCHEMBL21525583 | 0.79 | CTSA (0.50) | CTSA | |
| SCHEMBL21552119 | 0.76 | CTSA (0.45) | CTSA | |
| SCHEMBL6175673 | 0.76 | CTSA (0.45) | CTSA | |
| SCHEMBL6177067 | 0.76 | CTSA (0.45) | CTSA | |
| SCHEMBL6179589 | 0.76 | CTSA (0.45) | CTSA | |
| SCHEMBL6179952 | 0.76 | ALDH1A1 (0.44) | CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |