Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 14/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2039261 | 0.85 | CTSA (0.48) | CTSA | |
| SCHEMBL7825710 | 0.84 | CTSA (0.47) | CTSA | |
| SCHEMBL1975745 | 0.80 | FBP1 (0.39) | CTSAALDH1A1 | |
| SCHEMBL6254717 | 0.80 | CTSA (0.38) | CTSA | |
| SCHEMBL30218944 | 0.77 | ALDH1A1 (0.43) | CTSAALDH1A1HSPA5SMN1; SMN2 | |
| SCHEMBL6252040 | 0.77 | CTSA (0.40) | CTSAALDH1A1 | |
| SCHEMBL1975742 | 0.74 | ALDH1A1 (0.37) | CTSAALDH1A1 | |
| SCHEMBL13744445 | 0.74 | CYP1A2 (0.35) | CTSAALDH1A1HSPA5SMN1; SMN2 | |
| SCHEMBL2041450 | 0.73 | CTSA (0.46) | CTSA | |
| SCHEMBL5585939 | 0.73 | ALDH1A1 (0.43) | CTSAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324028-A2 | THERAPEUTIC AGENTS 414 | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010015849-A2 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-02-11 | — | — | WO | disclosed |
| EP-1590337-A1 | ACYLAMINOTHIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME AS BETA-AMYLOID PEPTIDE PRODUCTION INHIBITORS | Sanofi-Aventis (FR) | 2005-11-02 | — | — | EP | disclosed |
| WO-2004067520-A1 | ACYLAMINOTHIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME AS BETA-AMYLOID PEPTIDE PRODUCTION INHIBITORS | SANOFI-AVENTIS (FR) | 2004-08-12 | — | — | WO | disclosed |