SCHEMBL20397

SCHEMBL20397

Oc1[c]cc(Cl)cc1Cl

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28546860 0.77
SCHEMBL1638801 0.77
SCHEMBL27208 0.74
SCHEMBL838581 0.74
SCHEMBL6381071 0.72
SCHEMBL28565488 0.72 CYP3A4 (0.35)
SCHEMBL6646592 0.71 ALDH1A1 (0.52)
SCHEMBL260747 0.71
SCHEMBL11337530 0.71 LMNA (0.35)
SCHEMBL4336065 0.69 AKR1C2 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1461 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3201208-B1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2021-03-24 EP claimed
EP-3201207-B1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2021-02-24 EP claimed
EP-3201205-B1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2020-05-13 EP claimed
US-10640520-B2 Boronic acid derivatives MERCK PATENT GMBH (DE) 2020-05-05 US claimed
US-10294246-B2 Substituted boronic acids and boronate esters as immunoproteasome inhibitors MERCK PATENT GMBH (DE) 2019-05-21 US claimed
US-20180179231-A1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2018-06-28 US claimed
US-20180105539-A1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2018-04-19 US claimed
US-20180105538-A1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2018-04-19 US claimed
EP-2955173-B1 1,2-BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS ALLERGAN INC (US) 2017-10-04 EP claimed
EP-3201208-A1 BORONIC ACID DERIVATIVES Merck Patent GmbH (DE) 2017-08-09 EP claimed
US-6649613-B1 Integrin inhibitors MERCK PATENT GMBH (DE) 2003-11-18 US claimed
US-20030144195-A1 Therapeutic peptide-based constructs LITTLE ROGER G (US) 2003-07-31 US claimed
US-20030114457-A1 2- [5- (5-carbamimidoyl-1H-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinic acid derivatives as factor viia inhibitors AXYS PHARMACEUTICALS, INC. (US) 2003-06-19 US claimed
WO-2002070464-A2 HYDRAZONES AND THEIR THERAPEUTIC USE ARPIDA AG (CH) 2002-09-12 WO claimed
US-6423825-B1 OCTA-, NONA-, DECA- OR POLYPEPTIDE; HEPARIN BINDING AND NEUTRALIZATION; ANTIPROLIFERATIVE AGENTS OF ENDOTHELIAL CELLS; ANGIOGENESIS INHIBITORS XOMA TECHNOLOGY LTD. (BM) 2002-07-23 US claimed
EP-1196440-A2 THERAPEUTIC PEPTIDES DERIVED FROM SUBSEQUENCES OF BPI XOMA Technology Ltd. (US) 2002-04-17 EP claimed
US-6355616-B1 FUNGICIDE OLIGOPEOTIDES XOMA (US) TECHNOLOGY LTD. 2002-03-12 US claimed
WO-2001000655-A2 THERAPEUTIC PEPTIDES DERIVED FROM SUBSEQUENCES OF BPI XOMA TECHNOLOGY LTD. (US) 2001-01-04 WO claimed
WO-2001000671-A1 DERIVATIVE COMPOUNDS XOMA TECHNOLOGY LTD. (US) 2001-01-04 WO claimed
EP-0823426-A1 Xanthene and acridine derivatives and their use F. HOFFMANN-LA ROCHE AG (CH) 1998-02-11 EP claimed