Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20399930 | 0.83 | MGLL (0.51) | MGLLKMT2A | |
| SCHEMBL18423593 | 0.78 | MGLL (0.73) | MGLLHTR2AHTR2CALDH1A1MEN1 | |
| SCHEMBL18446121 | 0.76 | MGLL (0.46) | MGLL | |
| SCHEMBL3485901 | 0.76 | HTR2A (0.71) | HTR2AHTR2CSIGMAR1ALDH1A1MEN1 | |
| SCHEMBL21378223 | 0.76 | MGLL (0.54) | MGLLHTR2AHTR2CSIGMAR1ALDH1A1 | |
| SCHEMBL20399264 | 0.74 | MGLL (0.48) | MGLL | |
| SCHEMBL20399926 | 0.74 | MGLL (0.46) | MGLLALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL28077641 | 0.72 | TSHR (0.44) | MGLLHTR2AHTR2CSIGMAR1ALDH1A1 | |
| SCHEMBL18423071 | 0.70 | MGLL (0.58) | MGLL | |
| SCHEMBL18446124 | 0.69 | KDM4E (0.44) | MGLLHTR2AHTR2CALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018134698-A1 | HETEROCYCLIC SPIRO COMPOUNDS AS MAGL INHIBITORS | PFIZER INC. (US) | 2018-07-26 | — | — | WO | disclosed |