Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16565570 | 0.84 | TSHR (0.55) | TSHRSMN1; SMN2CYP2D6KDM4EHTR2A | |
| SCHEMBL16565507 | 0.83 | RORC (0.47) | TSHRMGLL | |
| SCHEMBL21078010 | 0.82 | HTR2A (0.42) | TSHRSMN1; SMN2CYP2D6HSD11B1KDM4E | |
| SCHEMBL16553664 | 0.80 | GRIN2D (0.46) | TSHRSMN1; SMN2CYP2D6HSD11B1KDM4E | |
| SCHEMBL17867827 | 0.79 | SMN1; SMN2 (0.37) | TSHRSMN1; SMN2GAACYP2D6HSD11B1 | |
| SCHEMBL18446124 | 0.77 | KDM4E (0.44) | TSHRSMN1; SMN2HSD11B1KDM4EADRB2 | |
| SCHEMBL16565682 | 0.76 | KMT2A (0.43) | TSHRSMN1; SMN2GAAHSD11B1KDM4E | |
| Hydrochloric Acid SCHEMBL16553822 | 0.75 | KMT2A (0.42) | TSHRSMN1; SMN2GAAHSD11B1KDM4E | |
| SCHEMBL3485901 | 0.72 | HTR2A (0.71) | GAAKDM4EHTR2AHTR2CKMT2A | |
| SCHEMBL20399228 | 0.72 | MGLL (0.48) | TSHRSMN1; SMN2GAAHSD11B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105745209-B | Triazolopyridine compounds, compositions, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-105745209-A | Triazolopyridine compounds, compositions, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2016-07-06 | — | — | CN | disclosed |