Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15710432 | 0.82 | MCL1 (0.33) | MEN1KMT2ADPP4 | |
| SCHEMBL16469656 | 0.75 | TSHR (0.40) | KMT2ATBXAS1TSHRTP53EGLN1 | |
| SCHEMBL16469655 | 0.75 | TSHR (0.40) | KMT2ATBXAS1TSHRTP53EGLN1 | |
| SCHEMBL3192914 | 0.75 | TBXAS1 (0.46) | TBXAS1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL3192910 | 0.75 | TBXAS1 (0.46) | TBXAS1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL4373237 | 0.73 | TSHR (0.38) | TBXAS1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL3200011 | 0.71 | TBXAS1 (0.55) | TBXAS1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL22070965 | 0.71 | HMGCR (0.44) | TBXAS1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL32684399 | 0.71 | TBXAS1 (0.37) | TBXAS1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL3204840 | 0.71 | TBXAS1 (0.51) | TBXAS1TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136401-A1 | IMMUNOPROTEASOME INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2018-07-26 | — | — | WO | disclosed |