Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2035761 | 0.82 | OPRL1 (0.40) | OPRL1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL2037649 | 0.78 | AKR1C1 (0.42) | OPRL1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL2035833 | 0.78 | AKR1C1 (0.42) | OPRL1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL2035878 | 0.74 | KDM4E (0.35) | OPRL1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL2040851 | 0.70 | LMNA (0.39) | OPRL1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL28794538 | 0.69 | OPRL1 (0.34) | OPRL1ALDH1A1 | |
| SCHEMBL2053963 | 0.68 | LMNA (0.36) | OPRL1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL3797646 | 0.68 | ALDH1A1 (0.35) | OPRL1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL2016931 | 0.67 | LMNA (0.38) | OPRL1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL2037379 | 0.66 | PDE4A (0.34) | OPRL1LMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |