Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.65 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.56 |
| ▸ | WNT3A | P56704 | 2/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.56 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828218 | 0.86 | MAPK1 (0.76) | MAPK1GPR84PIM3ALDH1A1PBRM1 | |
| SCHEMBL2005017 | 0.86 | MAPK1 (0.74) | MAPK1GPR84PIM3ALDH1A1PBRM1 | |
| SCHEMBL28059877 | 0.85 | MAPK1 (0.74) | MAPK1GPR84ALDH1A1PBRM1ATM | |
| Trifluoroacetic Acid SCHEMBL17895843 | 0.84 | MAPK1 (0.73) | MAPK1GPR84ALDH1A1PBRM1ATM | |
| SCHEMBL1607435 | 0.82 | MAPK1 (0.70) | MAPK1GPR84ALDH1A1PBRM1ATM | |
| SCHEMBL13543217 | 0.82 | MAPK1 (0.70) | MAPK1GPR84ALDH1A1PBRM1ATM | |
| SCHEMBL31530832 | 0.81 | MAPK1 (0.68) | MAPK1GPR84ALDH1A1PBRM1ATM | |
| Trifluoroacetic Acid SCHEMBL28105351 | 0.80 | ALDH1A1 (0.78) | MAPK1GPR84PIM3ALDH1A1PBRM1 | |
| SCHEMBL27943863 | 0.79 | GPR84 (0.71) | MAPK1GPR84ALDH1A1PBRM1ATM | |
| SCHEMBL7048104 | 0.79 | MAPK1 (0.65) | MAPK1GPR84ALDH1A1PBRM1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116574048-A | Bromination reaction method of remote indole C-H bond by using sunlight catalysis | 陕西科技大学 | 2023-08-11 | — | — | CN | claimed |
| CN-111825594-B | (Z) -beta-trifluoromethyl dehydrotryptophan compound and synthetic method and application thereof | 商丘师范学院 | 2022-03-29 | — | — | CN | claimed |
| CN-111825594-A | (Z) -beta-trifluoromethyl dehydrotryptophan compound and synthetic method and application thereof | 商丘师范学院 | 2020-10-27 | — | — | CN | claimed |
| CN-106946758-B | A kind of synthetic method of 3- (trifluoroacetyl) indole derivatives | 丽水学院 | 2019-11-19 | — | — | CN | claimed |
| CN-106946758-A | A kind of synthetic method of 3 (trifluoroacetyl) indole derivativeses | 丽水学院 | 2017-07-14 | — | — | CN | claimed |
| US-20150164860-A1 | ANTICANCER TREATMENT METHODS INVOLVING ANALOGS AND DERIVATIVES OF 3-(2-SUBSTITUTED-ETHYL) INDOLE COMPOUNDS | TUSKEGEE UNIVERSITY (US) | 2015-06-18 | — | — | US | claimed |
| EP-2142516-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | Sanofi-Aventis (FR) | 2010-01-13 | — | — | EP | claimed |
| WO-2008121670-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI-AVENTIS (FR) | 2008-10-09 | — | — | WO | claimed |
| US-12485109-B2 | Pyrrolo 12.3-dipyrimidine compounds and analogues thereof | BIOCRYST PHARMACEUTICALS, INC. (US) | 2025-12-02 | — | — | US | disclosed |
| US-20250236590-A1 | A METHOD FOR THE PREPARATION OF INDOLE-3-CARBOXYLIC ACID DERIVATIVES | DEB INDUBHUSAN | 2025-07-24 | — | — | US | disclosed |
| EP-4419503-A1 | A METHOD FOR THE PREPARATION OF INDOLE-3-CARBOXYLIC ACID DERIVATIVES | Council of Scientific and Industrial Research, an Indian Registered Body Incorporated under Regn. of Soc. Act (Act XXI of 1860) (IN) | 2024-08-28 | — | — | EP | disclosed |
| CN-118265698-A | Process for preparing indole-3-carboxylic acid derivatives | 科学与工业研究会(按照印度社会团体注册法案(1860年第21号法案)设立的注册机构) | 2024-06-28 | — | — | CN | disclosed |
| EP-3925956-B1 | 1H-INDAZOLE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS FACTOR D INHIBITORS FOR TREATING DISEASES CHARACTERIZED BY ABERRANT COMPLEMENT SYSTEM ACTIVITY, SUCH AS E.G. IMMUNOLOGICAL DISORDERS | BIOCRYST PHARM INC (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117603120-A | Preparation method and application of indole-3-fluoroketone compound | 平顶山学院 | 2024-02-27 | — | — | CN | disclosed |
| EP-0619297-A1 | Fungicides for the control of take-all desease of plants | MONSANTO COMPANY (US) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| CN-1078469-A | Substituted indole, the assorted indoles of ammonia and tetrahydro-1 H-pyrrolo be [2,3-c] pyridin-7-one derivatives also | SYTEX A INC (US) | 1993-11-17 | — | — | CN | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |
| US-4966913-A | FOR FALL ARMYWORM AND EUROPEAN CORN BORER | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1990-10-30 | — | — | US | disclosed |
| US-4942247-A | SULFIDE DERIVATIVES OF NITRILES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1990-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12485109-B2 | Pyrrolo 12.3-dipyrimidine compounds and analogues thereof | C5, DPYD, C9 | MAPK1 2178/4885GPR84 4602/4885PIM3 3051/4885 |
| US-20250236590-A1 | A METHOD FOR THE PREPARATION OF INDOLE-3-CARBOXYLIC ACID DERIVATIVES | IDO1, INMT, IDO2 | MAPK1 3508/4885GPR84 3010/4885PIM3 250/4885 |
| US-20150164860-A1 | ANTICANCER TREATMENT METHODS INVOLVING ANALOGS AND DERIVATIVES OF 3-(2-SUBSTITUTED-ETHYL) INDOLE COMPOUNDS | MCL1, BAD, API5 | MAPK1 3641/4885GPR84 3979/4885PIM3 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.