Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2568705 | 0.81 | MEN1 (0.55) | KMT2AMEN1L3MBTL1HPGDHTT | |
| SCHEMBL28546709 | 0.80 | PYCR1 (0.44) | KMT2AMEN1TAAR1PYCR1SLC6A2 | |
| SCHEMBL30435410 | 0.80 | PYCR1 (0.44) | KMT2AMEN1TAAR1PYCR1SLC6A2 | |
| SCHEMBL6898173 | 0.71 | L3MBTL1 (0.65) | KMT2AMEN1L3MBTL1HPGDTSHR | |
| SCHEMBL2509178 | 0.71 | L3MBTL1 (0.65) | KMT2AMEN1L3MBTL1HPGDTSHR | |
| SCHEMBL1983563 | 0.70 | L3MBTL1 (0.64) | KMT2AMEN1L3MBTL1HPGDTSHR | |
| SCHEMBL2367944 | 0.70 | L3MBTL1 (0.64) | KMT2AMEN1L3MBTL1HPGDTSHR | |
| SCHEMBL28555041 | 0.70 | PYCR1 (0.43) | KMT2AMEN1HPGDLMNATAAR1 | |
| SCHEMBL30435138 | 0.70 | PYCR1 (0.43) | KMT2AMEN1HPGDLMNATAAR1 | |
| SCHEMBL12237260 | 0.69 | KMT2A (0.56) | KMT2AMEN1L3MBTL1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351248-A1 | COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS | Ardelyx, Inc. (US) | 2018-07-25 | — | — | EP | disclosed |