Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637090 | 0.81 | KMT2A (0.47) | KMT2AHTTNPC1DYRK1AIDO1 | |
| SCHEMBL18430532 | 0.80 | KMT2A (0.46) | KMT2AHTTNPC1DYRK1AIDO1 | |
| SCHEMBL18053335 | 0.78 | NOS3 (0.52) | NPC1MAP4K4ALDH1A1PLAUNOS3 | |
| SCHEMBL10310875 | 0.78 | SMN1; SMN2 (0.34) | KMT2AHTTNPC1MAPTSMN1; SMN2 | |
| SCHEMBL17203338 | 0.78 | KMT2A (0.43) | KMT2AHTTNPC1DYRK1AIDO1 | |
| SCHEMBL17203284 | 0.78 | KMT2A (0.43) | KMT2AHTTNPC1DYRK1AIDO1 | |
| SCHEMBL1204465 | 0.78 | KMT2A (0.43) | KMT2AHTTNPC1DYRK1AIDO1 | |
| SCHEMBL2034977 | 0.77 | CSF1R (0.40) | HTTIDO1MAP4K4ABL1CSF1R | |
| SCHEMBL2039210 | 0.77 | NOS3 (0.32) | NPC1MAPTRAB9ANOS3NOS1 | |
| SCHEMBL17034515 | 0.77 | KMT2A (0.46) | KMT2AHTTNPC1DYRK1AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11944606-B2 | Azaindoles as inhibitors of HPK1 | GENENTECH, INC. (US) | 2024-04-02 | — | — | US | disclosed |
| EP-3596075-B1 | AZAINDOLES AS INHIBITORS OF HPK1 | HOFFMANN LA ROCHE (CH) | 2023-10-11 | — | — | EP | disclosed |
| EP-3596075-B1 | AZAINDOLES AS INHIBITORS OF HPK1 | HOFFMANN LA ROCHE (CH) | 2023-10-11 | — | — | EP | disclosed |
| EP-4209492-A1 | COMPOUND FOR TREATING THROMBOTIC DISEASES | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2023-07-12 | — | — | EP | disclosed |
| CN-110402248-B | Azaindoles as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-06 | — | — | CN | disclosed |
| US-20210299110-A1 | AZAINDOLES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2021-09-30 | — | — | US | disclosed |
| US-20210299110-A1 | AZAINDOLES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2021-09-30 | — | — | US | disclosed |
| US-10952995-B2 | Azaindoles as inhibitors of HPK1 | GENENTECH, INC. (US) | 2021-03-23 | — | — | US | disclosed |
| US-10952995-B2 | Azaindoles as inhibitors of HPK1 | GENENTECH, INC. (US) | 2021-03-23 | — | — | US | disclosed |
| WO-2020012424-A1 | SUBSTITUTED (AZA)INDOLE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2020-01-16 | — | — | WO | disclosed |
| US-20150239874-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED | 2015-08-27 | — | — | US | disclosed |
| US-9096584-B2 | Compounds useful as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140171407-A1 | 1,7-DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2014-06-19 | — | — | US | disclosed |
| US-20140171407-A1 | 1,7-DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2014-06-19 | — | — | US | disclosed |
| US-20140171407-A1 | 1,7-DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2014-06-19 | — | — | US | disclosed |
| EP-2513110-A1 | 1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| US-20120177748-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-12 | — | — | US | disclosed |
| US-20110183938-A1 | 1,7-DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2011-07-28 | — | — | US | disclosed |
| US-20110183938-A1 | 1,7-DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2011-07-28 | — | — | US | disclosed |
| WO-2011073263-A1 | 1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239874-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, CHEK1, MAP3K20 | KMT2A 1879/4885HTT 2450/4885NPC1 4041/4885 |
| US-20110183938-A1 | 1,7-DIAZACARBAZOLES AND METHODS OF USE | CHEK1, CHEK2, BUB1B | KMT2A 2280/4885HTT 4734/4885NPC1 2505/4885 |
| US-10952995-B2 | Azaindoles as inhibitors of HPK1 | HIPK1, HIPK2, PPIP5K2 | KMT2A 1022/4885HTT 2327/4885NPC1 1720/4885 |
| US-20140171407-A1 | 1,7-DIAZACARBAZOLES AND METHODS OF USE | CHEK1, CHEK2, BUB1B | KMT2A 2280/4885HTT 4734/4885NPC1 2505/4885 |
| US-11944606-B2 | Azaindoles as inhibitors of HPK1 | HIPK1, HIPK2, PPIP5K2 | KMT2A 1022/4885HTT 2327/4885NPC1 1720/4885 |
| US-20210299110-A1 | AZAINDOLES AS INHIBITORS OF HPK1 | HIPK1, HIPK2, PPIP5K2 | KMT2A 1022/4885HTT 2327/4885NPC1 1720/4885 |
| US-20120177748-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, CHEK1, MAP3K20 | KMT2A 1879/4885HTT 2450/4885NPC1 4041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.