Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20406250 | 0.85 | PDE10A (0.45) | PDE10AMEN1KMT2ARAB9ATDP1 | |
| SCHEMBL20406345 | 0.79 | PDE10A (0.45) | PDE10AALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL20406089 | 0.79 | L3MBTL1 (0.49) | PDE10AALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL20406612 | 0.77 | PDE10A (0.48) | PDE10AALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7910614 | 0.77 | KMT2A (0.59) | PDE10AALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20406212 | 0.77 | PDE10A (0.43) | PDE10AALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL4008329 | 0.74 | PDE10A (0.51) | PDE10AALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL20406610 | 0.73 | PDE10A (0.51) | PDE10AMEN1KMT2ARAB9ATDP1 | |
| SCHEMBL20406238 | 0.73 | PDE10A (0.48) | PDE10AALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL2488534 | 0.73 | RAB9A (0.56) | PDE10AALDH1A1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351533-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2018-07-25 | — | — | EP | disclosed |