Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20394291 | 0.89 | GAA (0.45) | GAAPDCD1CD274PDE10APDE1A | |
| SCHEMBL20406760 | 0.85 | PDE10A (0.40) | PDE10AMAPTL3MBTL1GRM2CYSLTR1 | |
| SCHEMBL20406528 | 0.81 | PDE10A (0.37) | GAAPDE10AMAPTL3MBTL1GRM2 | |
| SCHEMBL20406576 | 0.76 | PDE1A (0.42) | CD274PDE10APDE1APDE1BPDE1C | |
| SCHEMBL20406516 | 0.75 | KDM4E (0.38) | L3MBTL1MEN1KMT2A | |
| SCHEMBL20406167 | 0.75 | GRM2 (0.41) | PDE10AMAPTL3MBTL1GRM2CYSLTR1 | |
| SCHEMBL20406415 | 0.73 | AHR (0.39) | PDE10AMAPTMEN1KMT2A | |
| SCHEMBL20394233 | 0.72 | PDE10A (0.41) | PDE10AL3MBTL1MEN1KMT2A | |
| SCHEMBL20406654 | 0.72 | RORC (0.44) | PDE10AMAPTMEN1KMT2A | |
| SCHEMBL20406230 | 0.71 | MEN1 (0.37) | PDE10AMAPTL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351533-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2018-07-25 | — | — | EP | disclosed |