⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2046035 | 0.56 | — | — | |
| SCHEMBL2044069 | 0.55 | — | — | |
| SCHEMBL1228399 | 0.51 | — | — | |
| SCHEMBL8815916 | 0.43 | USP8 (0.37) | — | |
| SCHEMBL24676486 | 0.42 | — | — | |
| SCHEMBL3293710 | 0.42 | — | — | |
| SCHEMBL1993425 | 0.41 | MAPK1 (0.43) | — | |
| SCHEMBL60145 | 0.41 | TTR (0.50) | — | |
| SCHEMBL45942 | 0.41 | CA2 (0.69) | — | |
| SCHEMBL57168 | 0.40 | ALDH1A1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138418-B2 | For therapy of atherosclerosis and hypercholesterolemia; 5-Pentafluorophenylsulfonamidoindazole for example; increasing LDL receptor gene expression in a cell | AMGEN, INC. (US) | 2006-11-21 | — | — | US | claimed |
| US-6962929-B2 | Pentafluorobenzenesulfonamides and analogs | TULARIK INC. (US) | 2005-11-08 | — | — | US | claimed |
| EP-0939627-B1 | PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS | TULARIK INC (US) | 2003-09-10 | — | — | EP | claimed |
| EP-0896533-B1 | PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS | TULARIK INC (US) | 2003-09-10 | — | — | EP | claimed |
| US-20030162817-A1 | Pentafluorobenzenesulfonamides and analogs | TULARIK INC. | 2003-08-28 | — | — | US | claimed |
| EP-1334719-A2 | Pentafluorobenzenesulfonamides and analogs | TULARIK, INC. (US) | 2003-08-13 | — | — | EP | claimed |
| JP-3421350-B2 | — | — | 2003-06-30 | — | — | JP | claimed |
| US-20020143036-A1 | Pentafluorobenzenesulfonamides and analogs | TULARIK INC. | 2002-10-03 | — | — | US | claimed |
| JP-2000515545-A | — | — | 2000-11-21 | — | — | JP | claimed |
| EP-0939627-A4 | PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS | TULARIK INC (US) | 2000-10-04 | — | — | EP | claimed |
| EP-0939627-A1 | PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS | TULARIK, INC. (US) | 1999-09-08 | — | — | EP | claimed |
| EP-0896533-A4 | PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS | TULARIK INC (US) | 1999-04-28 | — | — | EP | claimed |
| EP-0896533-A2 | PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS | TULARIK, INC. (US) | 1999-02-17 | — | — | EP | claimed |
| WO-1998005315-A1 | PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS | TULARIK, INC. (US) | 1998-02-12 | — | — | WO | claimed |
| WO-1997030677-A2 | PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS | TULARIK, INC. (US) | 1997-08-28 | — | — | WO | claimed |
| EP-3131897-B1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2022-06-15 | — | — | EP | disclosed |
| CN-107001278-B | Tetrahydroisoquinoline derivatives | UCB生物制药私人有限公司 | 2020-11-24 | — | — | CN | disclosed |
| EP-0896533-A2 | PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS | TULARIK, INC. (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1998005315-A1 | PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS | TULARIK, INC. (US) | 1998-02-12 | — | — | WO | disclosed |
| WO-1997030677-A2 | PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS | TULARIK, INC. (US) | 1997-08-28 | — | — | WO | disclosed |